• Magnetic interactions between metal ions are usually describ

  2019-12-02

  

  Magnetic interactions between metal ions are usually described by superexchange via intermediate ligands. Although the general principles of the superexchange mechanism are essentially the same for d and f ions, calculations of exchange parameters for lanthanides are more difficult than for transiti

• The aim of the present study was to investigate

  2019-12-02

  

  The aim of the present study was to investigate the acute effects of THC on resting state alltrans neurophysiology, and to examine the impact of COMT genotype on these effects. Thirty-nine healthy volunteers participated in a randomised, placebo-controlled, crossover pharmacological MRI study. Acut

• When a hour delay period was implemented for the WRAM

  2019-12-02

  

  When a 6-hour delay muscarinic receptor antagonists was implemented for the WRAM, neither of the E2-treated groups (E2-only and E2 + Levo) differed in WMC errors between the postdelay trials and the baseline trials. This suggests that exogenous E2 treatment protected from a delay-induced impairment

• br Materials and methods br Results br Discussion

  2019-12-02

  

  Materials and methods Results Discussion Schistosome cercarial elastase secreted from the acetabular glands of cercariae is recognized to play a critical role in mammalian host skin penetration upon infection. The present study extends the understanding of biochemical and immunological prop

• br Acknowledgements br Introduction Laryngeal cancers are th

  2019-11-30

  

  Acknowledgements Introduction Laryngeal cancers are the most frequent cancers of the head and neck region and their occurrence is strongly associated with the exposure to cigarette smoke and the consumption of strong alcohols. Almost all laryngeal cancers are squamous cell carcinomas. Usually

• br Transparency document br Acknowledgments This work

  2019-11-30

  

  Transparency document Acknowledgments This work was supported by the Ministry of Education, Youth and Sports of the Czech Republic (the National Program of Sustainability I, Grants LO1204 and LO1304), by the Czech Science Foundation (15-17282Y) and by Palacký University Olomouc (IGA_PrF_2017_0

• Acidic substituents showed moderate biochemical activity

  2019-11-30

  

  Acidic substituents () showed moderate biochemical activity, but these compounds showed reduced cellular potency. Additional compounds bearing a carboxylic 5-Methyl-CTP were also prepared and tested (data not shown). All of acidic compounds showed low cellular potency regardless of their biochemica

• EP is the major receptor to mediate PGE induced inflammatory

  2019-11-30

  

  EP4 is the major receptor to mediate PGE2-induced inflammatory pain. EP4 is upregulated by bmn 673 in DRG neurons [16]. Intrathecal injection of the EP4 agonist produced pain responses [25]. Either systemic or local injection of EP4 antagonists relieves inflammatory pain [3], [16], [26]. However, t

• br Conflict of Interest br Statement of Authorship br Introd

  2019-11-30

  

  Conflict of Interest Statement of Authorship Introduction Plant endopeptidases are involved in many important biological processes. Recent developments in molecular biological techniques have revealed trace amounts of endopeptidases play essential roles in plant development, turnover of pho

• Besides being the only enzyme E is also the largest

  2019-11-30

  

  Besides being the only enzyme, E1 is also the largest and arguably most complex protein encoded by papillomaviruses. As the replicative helicase, E1 plays a central role in the viral life cycle. To do so, E1 engages in multiple protein–protein and protein–nucleic carbenoxolone interactions to creat

• Introduction Maintenance of genome integrity is essential

  2019-11-30

  

  Introduction Maintenance of genome integrity is essential for life, and faithful DNA replication and repair ensure this. One of the most important parameters for DNA maintenance is the regulation of optimal concentrations of the four 5′-deoxyribonucleoside-triphosphates (dNTPs) the precursors for D

• br Sphingosine kinase One of

  2019-11-30

  

  Sphingosine kinase One of the enzymes closely related to DGKs are the sphingosine kinases (SKs). These enzymes catalyze the conversion of sphingosine (Sph) to sphingosine-1-phosphate (S1P). SKs and DGKs are closely related lipid kinase in term of basic enzymology and the mechanism of regulation a

• Sampling sediments is usually performed

  2019-11-29

  

  Sampling sediments is usually performed with grab corers [16], [29]. The digested sludge analyzed by Ternes et al. [16] was taken directly from the digester and the activated sludge was obtained by bax inhibitor of the slurry of STPs [16]. Collected samples are transported under cooled conditions (+

• Repulsive interactions towards undesirable substrates are ar

  2019-11-29

  

  Repulsive interactions towards undesirable substrates are arguably a very efficient means to implement specificity [8]. In particular, it could be assumed that discrimination against a substrate that is larger than the cognate substrate may be achieved easily by restricting the active site and explo

• First of all it should be emphasized that

  2019-11-29

  

  First of all, it should be emphasized that, although cPLA2α manifests a marked selectivity for phospholipids that contain AA at the sn-2 position, this does not mean in any way that, in cells, the enzyme cannot hydrolyze other fatty acyl residues to a significant extent even if this occurs at a lowe

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