• In conclusion we have developed an

  2020-08-06

  

  In conclusion, we have developed an in vitro system for the study of feline macrophages which will allow further investigation of macrophage related diseases and the effects of therapy on these cells. The feline CSF-1R has been cloned and expressed in Ba/F3 SLIGKV-NH2 and used to assess the activity

• br Conclusions br Funding This

  2020-08-06

  

  Conclusions Funding This work was supported by Grant 1512-366261/758K and 961-386261/917K from the Innovation Foundation of the State of Rhineland-Palatinate, by the Collaborative Research Center SFB 553 (Project A7 to HK), and the DFG grant Li 1759/1-1 (to HK). This study was partly supported

• Recently PKC has emerged as an important regulator

  2020-08-06

  

  Recently, PKCε has emerged as an important regulator of CeA GABAergic transmission, CRF1 activity, and alcohol effects in acute alcohol models. Studies utilizing systemic knockout and intra-amygdala knockdown of PKCε have resulted in reduced alcohol intake, reduced alcohol intoxication, and altered

• D-Luciferin Taken together this study gives first insights i

  2020-08-06

  

  Taken together, this study gives first insights into the complex effect of DNMT inhibition on pattern separation. Acute administration of RG108 enhanced pattern separation performance measured with the OPS task and increased Bdnf1 expression. However, this effect was only acute, and was not present

• MTX is a major component of

  2020-08-06

  

  MTX is a major component of the curative treatment of childhood ALL, and the extent of accumulation of its active polyglutamates (MTXPG) determines its cytotoxicity and influences treatment response in childhood ALL. GGH converts long-chain MTXPG into shorter-chain MTXPG and ultimately into MTX, whi

• The relationship between the hazard function and

  2020-08-06

  

  The relationship between the hazard function and the survivor function (see more details in Allison\'s textbook [1]) is described as or as Hence, we can estimate the survival probability from the hazard function. In survival analysis, the hazard function can be represented by any probability distrib

• In S cerevisiae Mek a paralog of the checkpoint kinase

  2020-08-06

  

  In S. cerevisiae, Mek1, a paralog of the checkpoint kinase Chk2, mediates cell-cycle arrest in response to meiotic defects (Bailis and Roeder, 2000, Xu et al., 1997). Mek1 is associated with meiotic chromosome axes, where its activation requires interactions with two other axis proteins, Hop1 and Re

• The sequence substrate specificity of a protein kinase defin

  2020-08-06

  

  (2) The sequence substrate specificity of a protein kinase defines its preference for the amino PBIT sale sequence encompassing the phosphorylatable residue. This is also referred to as the consensus sequence of a protein kinase. This form of substrate specificity was initially derived from sequenci

• br Crystal structure of the E DNA helicase and the

  2020-08-05

  

  Crystal structure of the E1 DNA helicase and the mechanism of DNA unwinding Initiation of papillomavirus DNA replication Although it is generally accepted that replication of the viral genome in undifferentiated cells, in transient assays or in vitro involves a bi-directional replication fork,

• br Introduction Chemokine receptors interact

  2020-08-05

  

  Introduction Chemokine receptors interact with a group of peptide ligands of 8–10kDa and are indispensable for coordination of cell migration in diverse physiological processes such as development, angiogenesis, immune defence and neuroendocrine regulation. They belong to the largest rhodopsin fa

• This study focuses on mechanisms of reciprocity between

  2020-08-05

  

  This study focuses on mechanisms of reciprocity between DGTS and PC in fungi during Pi starvation. We report changes in expression of the BTA1 gene and two PC biosynthesis genes during phosphate starvation of F. velutipes culture. We describe the deduced amino limonin mg sequence and genomic structu

• Prolyl hydroxylation is a widely observed

  2020-08-05

  

  Prolyl hydroxylation is a widely observed post translational modification in collagen, an abundant animal protein. The high content (~13% per chain of the triple helical structure) of 4-hydroxyproline (Hyp,O) in collagen, togather with the natural abundance of collagen has led to the estimation tha

• HOIP s ability to build linear Ub

  2020-08-05

  

  HOIP\'s ability to build linear Ub chains arises from a unique domain that follows directly after the RING2 domain, the linear ubiquitin chain-determining domain (LDD) (Fig. 1). Structures have revealed that the LDD is structurally integrated into RING2, creating a single RING2–LDD unit (Fig. 2D) [4

• We propose two hypotheses to interpret

  2020-08-04

  

  We propose two hypotheses to interpret our findings. The first, ELR (+) CXC chemokines stimulate both CXCR-1 and CXCR-2 chemokine receptor while activating neutrophils; however CXCR-1 chemokine receptor seems to play more active role in the process of neutrophil migration as shown in previous studie

• br Results br Discussion Nuclear

  2020-08-04

  

  Results Discussion Nuclear export of vRNP was originally thought to be mediated by the NEP/CRM1 interaction (O\'Neill et al., 1998), but several later studies indicated a role for NP in vRNP nuclear export: for example, LMB inhibits nuclear export of vRNP in a NEP-independent manner (Elton et

16025 records 813/1069 page Previous Next First page 上5页 811812813814815 下5页 Last page