• br Materials and methods br

  2024-03-18

  

  Materials and methods Results Discussion Japanese encephalitis caused by JEV is characterized by Phleomycin neuron death. However, the underlying mechanism is not fully understood. We and other researchers have demonstrated that JEV induces apoptosis by ER stress-mediated IRE1/JNK and ROS-

• br Materials and methods br

  2024-03-18

  

  Materials and methods Results and discussion Conclusion Funding This work was supported by the Canadian Institute of Health Research (CIHR) [grant number FDN-148413] to PS, the National Science and Engineering Research Council of Canada (NSERC) [grant number CRD-399680] to ÉM, and the FR

• br Results br Discussion Using primarily

  2024-03-18

  

  Results Discussion Using primarily an electrophysiological analysis of dysbindin-deficient hippocampal neurons in cultures and slices, we have uncovered a previously unreported role for dysbindin in enhancing CA3–CA1 AMPAR-mediated transmission. An earlier study, however, has reported a reduct

• Another issue is that the vast majority

  2024-03-18

  

  Another issue is that the vast majority of data from PET and CSF are from selected participants recruited through tertiary care dementia centers [176]. It is widely recognized that clinic-based participants differ from community-based studies, for example, the amount, type, and distribution of neuro

• br Discussion Missense mutations transversions

  2024-03-18

  

  Discussion Missense mutations (transversions) of the first nucleotide of the phenylalanine 69 2 mg at position 1174 (F1174) of the anaplastic lymphoma kinase gene can result in substitutions to leucine or valine (F1174L/V) while missense mutation (transversion) of the second nucleotide of the ph

• br Disclosure br Acknowledgments br Introduction Deeper unde

  2024-03-18

  

  Disclosure Acknowledgments Introduction Deeper understanding of the pathobiology of non-small cell lung cancer (NSCLC) has led to the development of small KPT-9274 that target genetic mutations known to play critical roles in the progression to metastatic disease. Mutations in epidermal gro

• There are two ways to transport FFAs into cells First

  2024-03-18

  

  There are two ways to transport FFAs into cells. First by passive diffusion. Second as the putative long-chain fatty CPI-455 australia transporters are proposed, CD36 the plasma membrane-associated fatty acid-binding protein (FABPpm) and fatty acid transport proteins (FATP) [11], where CD36 is resp

• br Material and methods br Results br Discussion GRK

  2024-03-18

  

  Material and methods Results Discussion GRK2 activity has increasingly been shown to contribute to the progression of numerous diseases and organ dysfunction [5], [6]. For instance, a large body of work over the last two decades has identified GRK2 as a major regulator of cardiac dysfunctio

• br Acknowledgments This work was supported by Grant in aid

  2024-03-18

  

  Acknowledgments This work was supported by Grant-in-aid for Scientific Research (S) (20229008) (to T.K.), Targeted Proteins Research Program (to T.K.), the Global COE Research Program (to T.K.) and Translational Systems Biology and Medicine Initiative (to T.K.) from the Ministry of Education, Cul

• In young animals the HT A receptor antagonist ketanserin at

  2024-03-18

  

  In young animals, the 5-HT2A 2797 synthesis antagonist ketanserin, at relatively low concentrations, shifted 5-HT concentration-response curves rightward, suggesting a role for 5-HT2A receptors in mediating 5-HT-induced contractions of the ureter. The slopes of the ketanserin Schild plots for the a

• Encouraged by this observation a

  2024-03-16

  

  Encouraged by this observation, a systematic SAR study on the A ring -alkoxy was conducted as summarized in . The A ring methoxy-containing KRCA-0008 was proven an optimal substituent in terms of potency after all and its bigger size derivatives were detrimental in both biochemical and H3122 cellula

• Nexturastat A The biological characteristics of cancer invas

  2024-03-16

  

  The biological characteristics of cancer invasion and metastasis are mainly attributed to the poor prognosis in cancer. It has been reported that overexpression of Ack1 promoted the migratory and invasive properties of breast cancer Nexturastat A by sustaining expression of epidermal growth factor.

• br Experimental section br Conflicts of

  2024-03-16

  

  Experimental section Conflicts of interest Acknowledgments This work was partly supported by INSA-Rouen, Rouen University, CNRS, Labex SynOrg (ANR-11-LABX-0029), Région Haute-Normandie. Introduction A key component of the integrated management of key pests such as codling moth (Cydia po

• NSAIDs induce gastrointestinal toxicity and

  2024-03-16

  

  NSAIDs induce gastrointestinal toxicity and evoke monobenzone by decreasing the production of gastroprotective prostanoids and by redirecting the COX substrate AA into LT biosynthesis, thereby causing vasoconstriction in gastric mucosa and airways (Celotti and Laufer, 2001; Koeberle and Werz, 2015;

• Acknowledgments br Introduction Pulmonary fibrosis

  2024-03-16

  

  Acknowledgments Introduction Pulmonary fibrosis (PF) is a chronic, fibrosing interstitial pneumonia and a crushing disease that occurs as a result of a variety of lung injuries, including auto-immune, tuberculosis and traumatic insult [1], [2]. PF is characterized by the accumulation of extracel

16016 records 162/1068 page Previous Next First page 上5页 161162163164165 下5页 Last page