• We have received funding from

  2019-04-22

  

  We have received funding from the Wellcome Trust to develop a global atlas of podoconiosis. We aim to advance new knowledge on the geographical distribution and spatial epidemiology of the disease. A first step in this work will be to establish the geographical absence of disease by applying an evid

• Adenosine is an important factor

  2019-04-22

  

  Adenosine is an important factor to participate the generation of ATP. What’s more, adenosine has significant endogenous protective effect such as suppressing the release of excitatory amino acid, reducing the permeability of cell membrane to calcium ion, expanding blood vessel of brain, preventing

• Although a well experienced group reported a

  2019-04-22

  

  Although a well experienced group reported a very high success rate of 80% after catheter ablation even in patients with congestive heart failure [40], the evidence described above suggests that catheter ablation alone is not sufficient to treat AF in patients with hemodynamic deterioration. This in

• Cell adhesion to extracellular matrix requires

  2019-04-22

  

  Cell adhesion to extracellular matrix requires the interaction of different molecules like selectins, cadherins and integrins [21]. Especially αvβ3 integrin has been proposed to mediate the adhesion of malignant cells in different entities such as multiple myeloma and breast cancer [22,23]. Upon exp

• In silico prediction software SIFT PolyPhen

  2019-04-22

  

  In silico prediction software, SIFT [51], PolyPhen2 [52], CADD [53], and other prediction systems are useful to evaluate a specific mutation which is detected in a patient. However, even if the in silico software predicts a mutation as pathogenic, we need to examine whether the genetic result is com

• To date over mutations in KCNQ

  2019-04-22

  

  To date, over 250 mutations in KCNQ1 have been found to be linked to LQT1 [34] and new LQT1 causing mutations continue to be identified. The vast majority of KCNQ1 mutations are single nucleotide substitutions (missense) or small insertion/deletions that localize to the S1-S6 transmembrane domains [

• It s finally a year by the end

  2019-04-22

  

  It\'s finally 2015: a year by the end of which extreme poverty and hunger are to be eradicated, maternal and child mortality are to be drastically reduced, and the trajectory of the global incidence of HIV, tuberculosis, and malaria are to be reversed. Much has been written about where the Millenniu

• El sujeto de la enunciaci n se subordina

  2019-04-22

  

  El sujeto de la enunciación se subordina MLN 9708 la autoridad y dominio del príncipe y, por interpósita persona del rey, como súbdito y leal servidor: “[…] tuve por conveniente servir a vuestra alteza con este sumario brevísimo de muy difusa hystoria que de los estragos e perdiciones acaecidas se p

• Los v nculos que el

  2019-04-22

  

  Los vínculos que el ensayista conservó con los intelectuales mexicanos fueron profusos y perdurables, en tanto continuaron hasta sus últimos años de vida, aun durante su estadía en la Cuba revolucionaria de principios de los años sesenta. Así, en 1959 inició lo que Ángel Rama denominó el ciclo cuban

• Case report A previously healthy

  2019-04-22

  

  Case report A previously healthy 37-year-old man was referred to our hospital in September 2015 with fever (between 37 and 38°C) for 10 days and general malaise. There was no history of recent travel, and the patient had no animals in his home. There were no remarkable features in the heart, lungs,

• Delegates emphasised the urgent need for a

  2019-04-22

  

  Delegates emphasised the urgent need for a consensus regarding the standards and guidelines among stakeholders in Kenya and Uganda. In addition, a common interpretation of the legal environment was considered crucial, and therefore the constitution and penal code would need to be harmonised in both

• The disproportionately low levels of national

  2019-04-22

  

  The disproportionately low levels of national and international attention paid to NCDs in terms of action plans, funding, and global institutions might be partly attributable to the framing of these conditions. After all, “anything that begins with ‘non’ may be considered a ‘non-issue’ or a ‘non-sta

• In this issue of Mark Nicol and colleagues report the

  2019-04-20

  

  In this issue of , Mark Nicol and colleagues report the diagnostic accuracy of two commercially available rapid urine tests to identify active tuberculosis in children. Lipoarabinomannan is a unique component of the mycobacterial GSK-J1 sodium salt that is excreted in the urine of some patients wit

• Introduction Hepatosplenic T cell lymphoma HSTCL is a

  2019-04-20

  

  Introduction Hepatosplenic T-cell lymphoma (HSTCL) is a rare subtype of peripheral T-cell lymphoma, which is derived from cytotoxic T-cells typically expressing γδ T-cell receptor (TCR). It usually occurs in young men and is characterized by B symptoms such as a fever, weight loss and night sweats,

• br D microCT data Bone volume BV

  2019-04-20

  

  3D microCT data Bone volume (BV/TV) ranged from 10.8 to 13.5% consistent with the published literature [18]. Trabecular thickness (Tb.Th), trabecular prostaglandin receptors (Tb.Sp), trabecular number (Tb.N) and bone surface per tissue area (BS/TV) values were also consistent with the range publ

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