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Pilsicainide might increase hERG proteins via
2019-05-22
Pilsicainide might increase hERG proteins via facilitating the transcription of hERG from DNA to RNA or the translation of hERG RNA into hERG protein. Qualitative RT-PCR demonstrated the absence of an increase in hERG mRNA expression levels after pilsicainide treatment (Supplemental Fig. S2), indic
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Tobacco use is poised to kill
2019-05-22
Tobacco use is poised to kill as many as 1 billion people in the 21st century, primarily from non-communicable diseases. Less often noted is the effect of tobacco use and second-hand smoke exposure on maternal and child health. Cigarette smoking during pregnancy poses serious risk to the mother and
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La categorizaci n propuesta por Margaret Randall es
2019-05-21
La categorización propuesta por Margaret Randall es mucho más simple, puesto que distingue tan sólo entre aquellos testimonios en sí de los testimonios para sí. Christina Dupláa analiza tal distinción: Como puede verse, la clasificación es bastante difusa, ya que en la primera categoría se consider
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Sendo o propositor da lei das os
2019-05-21
Sendo o propositor da lei das os, Bresser Pereira as definiu como entidades sem fim lucrativo, públicas não estatais, financiadas pelo Estado e por ele controladas através de contrato de gestão com fxação de indicadores de desempenho. Dessa forma proporcionariam maior autonomia e flexibilidade das a
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dna ligase It is important to know whether pilsicainide can
2019-05-21
It is important to know whether pilsicainide can be used as a therapeutic agent for LQT2 patients; and if so, we should determine the types of LQT2 mutation carriers to whom pilsicainide could be administered. As shown in Fig. 8, we examined the effects of pilsicainide on two mutant hERG proteins, G
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Significant uncertainty remains about the precise
2019-05-21
Significant uncertainty remains about the precise vectors, the plasticity of vector host-selection (ie, monkey human) and the exact location of vector exposure that results in human transmission of especially across different parts of Asia. In particular, uncertainty exists as to whether transmissio
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Now consider a Special Report
2019-05-21
Now consider a Special Report by the WHO Ebola Response Team. In it, the authors rightly—if not tautologically—suggest that shortening the delay to isolation of Ebola virus disease suspects would lead to quicker overall outbreak containment, yet they fail to adequately discuss the reality that suspe
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Self reported health SRH is
2019-05-21
Self-reported health (SRH) is considered to be a valuable source of data on various aspects of general health. In fact, it is one of the most widely used indicators of health status in survey research, and is recommended by the World Health Organization. SRH can be influenced by individual determina
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order Ro 31-8220 methanesulfonate br Study limitations br In
2019-05-20
Study limitations Introduction The spread of basic life support (BLS), including use of automated external defibrillators in the general public, may increase the chance of survival from sudden cardiac death (SCD). Survivors usually have underlying cardiac diseases, such as coronary artery dise
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Importance of heart failure Acute decompensated heart failur
2019-05-20
Importance of Bafilomycin A1 cost failure Acute decompensated heart failure (ADHF) refers to a clinical condition of worsening HF with dyspnea, often with evidence of fluid overload [1]. This is generally triggered by 1 of the 4 main factors: atrial fibrillation, anemia, hypertension, and medicati
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Una condici n sine qua non es la institucionalizaci
2019-05-20
Una condición sine qua non es la institucionalización de la autonomía de las fuerzas armadas respecto del poder civil, un rasgo específico, del militarismo latinoamericano que ha hecho del Estado de excepción, la norma. En Guatemala, la misma se remonta GS-9973 la Constitución de 1945 y al estatuto
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Un segundo aspecto que deber a ser considerado
2019-05-20
Un segundo aspecto que debería ser considerado para entender cabalmente por qué estas parentelas nobiliarias indígenas de Xolloco Acatla mostrarían una notable reluctancia Tubastatin A relacionarse con los poderes de San Pablo, y, por el contrario, habrían exhibido una interesada vinculación con los
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More than structural haemoglobin variants have
2019-05-20
More than 900 structural haemoglobin variants have been described. Of these more than 100 show high oxygen affinity [2]. Erythrocytosis caused by Hb Ypsilanti was first described in 1967 [3], and the mutation results in substitution of amino EPZ005687 (β99 Asp→Tyr) involved in the stability of the
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Rabies has no cure and by the
2019-05-20
Rabies has no cure, and by the time of clinical onset it is invariably fatal. More than 95% of deaths occur in Africa and Asia, 80% of which are in people living in rural, underserved populations, most of whom are children. Community awareness about the power of preventing dog bites and of life-savi
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We did a qualitative analysis to estimate the potential risk
2019-05-20
We did a qualitative analysis to estimate the potential risk of Zika GSK503 introduction into the country. We used the circlize statistical package for R software to visualise incoming traffic (logarithm of relative passenger volume) to Pakistani airports from countries characterised as Zika-virus-
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